ADIRA is…a disease? And Spencer Hagen knew about it and he’s been covering it up for years? I would never have thought (at least not the first part,) but it makes a lot of other things make sense - like the issues G6 has with diagnosing inflammatory issues, Sanial’s refusal to share their colloid coating technology…it’s sounding like the “adira” search may have existed so that if anyone started getting too close to the truth, they could be targeted and conditioned away from thinking about it.
Various versions of the same info are found on three articles:
In the ADIRA Revelations section on the ADIRA Article
On October 9th 2049, Sunil Cariappa published a data package to Vessel containing a body of research into acquired deficiency of the interleukin-1 receptor antagonist (ADIRA). [5] This research was conducted by Connie Muren, who alleged that the adira search term was part of a clandestine G6 operation to suppress the existence of ADIRA. Zhupao has not commented on Muren’s allegations.
From the Disappearance section on Cariappa’s article:
On October 9th 2049, Cariappa published a data package to Vessel containing a body of research into acquired deficiency of the interleukin-1 receptor antagonist (ADIRA). [14] The package included a recorded message in which Cariappa attributed the research to the “incredible bravery” of Muren, and read aloud a message from her that implicated Hagen in the suppression of ADIRA’s existence through the abuse of G6.
Interpol has determined that the data package was published from a location in Dharwad. Many individuals have come out in support of Cariappa, including Brad Berkemier, Laura McDonald, Sofia Peña, Kelly Rose, and Jagrati Thass.
There’s a bit more information in the section about Connie Muren’s death:
On October 9th 2049, Cariappa published a data package to Vessel containing a body of research into acquired deficiency of the interleukin-1 receptor antagonist (ADIRA). [10] The package included a recording in which Cariappa attributed the research to the “incredible bravery” of Muren, and read aloud a message from her that implicated Hagen in the suppression of ADIRA’s existence through the abuse of G6. Muren also accused Hagen of having attempted to kill her and threatened Cariappa’s life after she informed him of ADIRA on March 3rd 2040.
And all of this information collects and expands a bit in Spencer Hagen’s article, helpfully filed under ADIRA cover-up:
On October 9th 2049, Connie Muren posthumously accused Hagen of abusing G6 to cover up her discovery of acquired deficiency of the interleukin-1 receptor antagonist (ADIRA). Muren has described ADIRA as a variant of deficiency of the interleukin-1 receptor antagonist (DIRA) caused by the protein-based implanting method used by colloids, specifically the interleukin-1 receptor antagonist (IL-1RA) protein.
According to private research conducted by Muren, the pathology of ADIRA is linked to misfolding IL-1RA proteins, which are synthesised by colloids to prevent their electrodes from causing brain tissue inflammation. Muren attributed the misfolding to errors in the bioreactors used by colloids to express surface proteins, resulting from Hagen using unvetted language models to generate IL-1RA protein sequences while claiming to have licensed verified AlphaFold sequences. [23]
In a message read by Cariappa, who has published Muren’s ADIRA research to Vessel, Muren claims that she informed Hagen of her discovery on the night of March 3rd 2040, and that he reacted by attempting to murder her and threatening Cariappa’s life “in order to suppress ADIRA.” Interpol has indicated that it will “take these new elements in the disappearance and death of Connie Muren into account.”
Edit to add citation 23 from Hagen’s article:
23. Madani, A; Krause, B; Greene, E et al. (January 2023). “Large language models generate functional protein sequences across diverse families.” Nature Biotechnology. 
